13. Darren Sproles, 2005
Like Brees, Darren Sproles was not on the Chargers for very long and a lot of his career impact came with other teams. That being said, Sproles definitely still left an impact on the Chargers as one of the best returners in team history. Plus, Spoles had one of the best playoff games in franchise history against the Indianapolis Colts when LaDainian Tomlinson got hurt.
The Chargers selected Sproles in the fifth round of the 2005 NFL Draft. While there are a lot of solid running backs that go late in the draft, landing someone of Sproles caliber in the fifth round is still no small feat. If he would have played on the Chargers longer then he could have ranked slightly higher on this list.
12. Vincent Jackson, 2005
The Chargers had some fantastic selections in the 2005 NFL Draft. Shawne Merriman was a solid pick in the first round, although the lack of longevity keeps him off this list. Luis Castillo was an okay selection with the team's second first-round pick in 2005 and then the Chargers followed that with Vincent Jackson in the second round.
Jackson became Philip Rivers' go-to receiver on the Bolts and had a good half-decade run where he was one of the most dominant receivers in the league. Jackson had two Pro Bowl seasons with the Bolts and three seasons with over 1,000 receiving yards.
Outside of an injury-plagued 2010 season, Jackson had 1,000+ receiving yards every season from 2008 to 2014. That is no small feat and landing that kind of no. 1 receiver in the second round, even if he left for Tampa Bay, is worth mentioning.