Comparing the LA Chargers defense and Kansas City Chiefs defense:
Interior defensive line: Advantage, LA Chargers
Both interior defensive lines are not doing too good especially with the fact that Justin Jones is still hurt for the LA Chargers. Both teams are fairly mediocre in who they are throwing out there on the inside and the main difference maker is Linval Joseph.
Even at his old age, Joseph is the best defensive tackle in this game and he needs to have a great game to keep the Chiefs from being able to run the ball. While everyone might be expecting a passing showdown, perhaps we will instead get a running showdown.
Edge rushers: Advantage, LA Chargers
Both Frank Clark and Chris Jones are on the Chiefs injury report and with that in mind, the LA Chargers get the nod. Joey Bosa is the best edge rusher of either team anyways and the Chiefs not having their two guys at 100% will make an impact.
Linebackers: Advantage, LA Chargers
Kenneth Murray did not have a great game last week after getting banged up and Drue Tranquill has not played as many snaps as expected before the season but I would still take the Chargers' linebackers before the Chiefs' linebackers any day of the week.
Anthony Hitchens is an okay linebacker who could be better against the run but I would probably still take the explosive Murray over him. Both Kyzir White and Tranquill are better than the other options the Chiefs have, which is music to the Chargers' ears.
Cornerbacks: Advantage, LA Chargers
Chris Harris' status for this game is going to be huge as he is the best run-defending cornerback that the team has. But even without him, in terms of coverage, the Chargers are the better team at the cornerback position.
Mike Hughes is okay and L'Jarius Sneed is nothing special. Michael Davis has been fine to start the season and Asante Samuel Jr. had a really solid Week 2 showing against the Dallas Cowboys.
Safeties: Advantage, LA Chargers
The LA Chargers sweep the defense, although I would not say any of their advantages are necessarily huge advantages. Here the math is simple: both teams have a combination of decent safeties with one standout safety each: Derwin James vs. Tyrann Mathieu.
Mathieu has had a great career and is still a solid safety but he is no Derwin James. James is the best of the bunch and swings the advantage in favor of the Bolts.