3. Alex Singleton and the Broncos' linebacker core (or just Denver's run defense in general)
Josey Jewell is the best inside linebacker that the Denver Broncos have and it does not seem like he is going to play on Monday with a knee issue from Week 5 that has made him week-to-week. If he does play, he is not going to be 100% in this game.
Regardless of if he does play or not, the Broncos' run defense has been sneaky bad this season despite the overall defensive numbers being pretty good. There is definitely a weak point on this defense to attack and the Chargers should be doing so with Austin Ekeler and Joshua Kelley.
Ekeler has had two monster games in the last two weeks and we have seen what getting the run game going does for this offense. The Chargers would be foolish to go away from that, especially when the book is out on how to torch this Broncos' run defense.
Josh Jacobs just put on a field clinic two weeks ago against the Broncos both on the ground and in the passing game. Austin Ekeler may not have to carry the ball 28 times alone but if it is working, we could see the run total creep up in that ballpark for the Bolts.
Indianapolis had some success running the ball last week with the team's third and fourth running back taking up the main workload. When Deon Jackson and Phillip Lindsay combine for 102 rushing yards it probably is not a great sign.
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Something has definitely been exposed in this Denver defense and if Alex Singleton is the team's best inside backer on Monday night then the Chargers will expose it even further.