Chargers vs Chiefs odds and prediction for Week 11 rematch

The last time the LA Chargers and Kansas City Chiefs faced off it was the first-ever Thursday Night Football game on Amazon Prime. It was also a game where the Chargers looked like the better team throughout. The Bolts were robbed of multiple interceptions that would have flipped the game and the team made one huge mistake in a key spot that lost them the game.

Things have been a lot different since that game. Herbert fractured rib cartilage near the end of that game and has not been the same up until the week after the Chargers' bye. The rest of the roster has been plagued with injuries and this Chargers team in Week 11 looks nothing like it did in Week 2. The Bolts have not played as well as they did in Week 2 since that game.

Meanwhile, the Chiefs have found a groove after losing to the Indianapolis Colts and are currently the no. 1 seed in the AFC. While they might not be as dominant as they were before, they still have the best offense in football and are firing on all cylinders.

That makes this Week 11 rematch an interesting one that should be a lot different than the game earlier this season. Vegas certainly seems to like the Chiefs more nine weeks later, as they are a bigger favorite than they were in Week 2.

Chargers vs Chiefs odds Week 11:

The Chargers are currently 6.5-point underdogs at home against the Chiefs. This makes the Bolts a +240 moneyline underdog, while the Chiefs check in as a -295 moneyline favorite. There is slightly more juice on the Chiefs' spread, with Chargers +6.5 having +108 odds.

The over/under for this game has been placed at 50 points. That makes it the highest point-total line for any game in the Week 11 slate.

Chargers vs Chiefs prediction Week 11:

The Chargers are hard to gauge as Mike Williams and Keenan Allen are supposed to return to practice this week but their status for the game is up in the air. Those two playing obviously make a huge difference for an offense that would no longer have to strut out practice squad players.

The Chiefs are also dealing with an injury to their receiving corps as well as Juju Smith-Schuster, who as emerged as the WR1 in recent weeks, will miss the game after suffering a scary concussion in Week 10 against the Jacksonville Jaguars.

While the status of the Chargers' WR duo is still up in the air, I like the Chargers as home dogs in this spot. The team has always played well against the Chiefs and they do have their Travis Kelce stopper in Derwin James, which makes a huge difference.

The Chargers' biggest hole defensively is their ability to stop the run and the Chiefs are not a team that is going to be able to exploit that like other teams. With a less-than-stellar defense of their own, you have to like the Chargers to cover in this game.

All that being said, I am going Chargers +6.5 and over 50 points. The Chargers have covered a 6.5-point line in each of the team's last five matchups against the Chiefs, winning two of those games and losing the other three within six points.

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The final score will be Chiefs 30, Chargers 26.

Game odds refresh periodically and are subject to change.