New England Patriots over Buffalo Bills
Nobody likes rooting for the Patriots, especially considering that the team is good again and is leading the AFC East. While these are both AFC playoff teams and Charger fans might want to stay as far away from the Patriots as possible, it is better for New England to win this game and sweep the Bills.
The Bills winning this game would only further complicate things in the AFC. As it currently stands, the Bills are tied with the Chargers with an 8-6 record and the Patriots are leading the division with a 9-5 record. A loss for the Pats puts all three teams at 9-6, which isn't what the Chargers want.
If Buffalo wins they will then be the leader of the AFC East, pushing the Patriots down to a wild-card spot. That is not good for the Chargers as the Bolts have the tiebreaker over the Bills but do not have the tiebreaker over the Patriots, if it came down to being a head-to-head tiebreaker.
At the end of the day, it is better for the Chargers if the Patriots defeat the Bills, stay ahead of the Chargers anyway and get rid of one of the 8-6 teams in the AFC. Adding more teams to the mix with the same record is the last thing that the Bolts need in the final two weeks.