- Drue Tranquill, Linebacker – Questionable (Back)
- Denzel Perryman, Linebacker – Questionable (Ankle)
- Jatavis Brown, Linebacker – Doubtful (Ankle)
Perryman and Tranquill seem likely to play this weekend, while Brown does not appear ready. Brown is important depth, but it was unlikely that he was going to be heavily utilized in this game.
However, against a hard-nosed running team like the Colts, the Chargers will want as many sure-tackling players as possible. If Perryman and Tranquill are limited or are on a snap count, that could be impactful as smaller linebackers (such as Kyzir White) are forced to play in their stead.
- Trevor Williams, Cornerback – Out (Quad)
After being expected to compete for the starting outside cornerback slot, Williams has unfortunately suffered an injury and appears out for the time being.
Without Williams, Michael Davis will be tasked with covering the WR2 (Devin Funchess). Expect Brandon Facyson or a safety to take Williams’ place in dime packages.
- Derwin James, Safety – Out (Foot)
The loss of James will almost certainly be the most significant missing player for the Chargers defense every week until he returns.
The impact of this loss is a bit difficult to define due to his versatility; James is a versatile piece for Gus Bradley, as he plays nearly every position on the field.
His spot at strong safety will be primarily occupied by the similarly-versatile Adrian Phillips.
Phillips excels as a tackler, which will likely be needed to contain the Colts’ running backs, as they reach the second level of the defense behind a great offensive line.
However, Phillips lacks a bit of speed in coverage compared to James, so he may be tested by the Colts receivers in the middle of the field. Look for the Chargers to consider using a speedy linebacker (such as White) to help Phillips in coverage against players like Eric Ebron.
- Roderic Teamer Jr, Safety – Doubtful (Hamstring)
For now, Teamer is expected to be strictly a special teams player, so his absence leaves no void in the defense.